Autophagy in the cancer-immunity dialogue

Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic cells, explaining why both normal and malignant cells benefit from proficient autophagic responses. Moreover, autophagy intimately involved immunological control transformation, tumor progression response to therapy. However, net effect activation or inhibition on natural growth therapeutic tumors evolving immunocompetent hosts exhibits a considerable degree context dependency. Here, we discuss complex cross-talk between immuno-oncology as delineated by genetic pharmacological approaches mouse models cancer.